DEVELOPMENT

IDEHALER®-NEBULIZERS

THE MOST EFFECTIVE NEBULISATION SYSTEM OF DTF FOR LUNG DELIVERY

The mesh technology of DTF

Color gradient of the deformation of the material
  


Two available devices

  • The idehaler mesh nebulizer: it could be used as an aerosol generator:
    - to reduce treatment times and
    - achieve high lung deposition for new drugs, making it suitable for biodrugs in development (based on in vitro and ex vivo studies).

     
  • The idehaler pocket nebulizer: the mesh nebulizer with a virtual valve holding chamber offers the advantage to be:
    - very small, portable,
    - easy to use.

Pipeline

We can adapt the device to your drug.
PRODUCTINDICATIONPRECLINICALPH I PH II PH III MARKET PARTNER
Antibiotic Cystic Firosis -------------------- ------ ----->     Erempharma
Magnesium Sulfate (MgSO4) Asthma (Peadiatric) -------------------- ----->       University of Toronto
ALX-009 Cystic Fibrosis ------------------->         Alaxia and Stragen

Ac anti-ricine Military medicine ------------------->         French army(DGA)
Phage Ventilator-associated pneumonia ------------------->         Pherecides pharma
Cyp0150 Influenza ------------------->         Cytune pharma

References

-  In vitro/in vivo comparison of inhaled aerosol from a hand-held nebulizer for administration of amikacin. Fink J, Kadrichu N, Gribben D, Corkery K. ISAM, 2007
- Testing of nebulizers for delivering magnesium sulfate to pediatric asthma patients in the emergency department. Coates AL, Leung K, Vecellio L, Schuh S. Respir Care. 2011 Mar;56(3):314-8. Pubmed abstract
- Aerosolized gemcitabine in Patients with carcinoma of the lung: feasibility and safety study. Lemarie E, Vecellio L, Hureaux J, Prunier C, Valat C, Grimbert D, Boidron-Celle M, Giraudeau B, Le Pape A, Pichon E, Diot P, El Houfia A, Gagnadoux F. J. Aerosol Med and Pulmonary Drug Delivery, 2011, 24 (6):261-270. Pubmed abstract
- Feasibility study of OSCN- and Lactoferrin (Meveol®) nebulization for cystic fibrosis patients. Perrotto S, Le Guellec S, Vecellio L, Fichant E, Stordeur P, Bordeau P, Perraudin JP. 34 th ECFS, 2011 and DDL21, 2010 with abstract available on JAM, 2011, 24(6):330. Poster PDF file
- Respiratory System Deposition with a Novel Aerosol Delivery System in Spontaneously Breathing Healthy Adults. Coates AL, Leung K, Chan J, Ribeiro N, Charron M, Schuh S. Respir Care. 2013 Jun 18. Pubmed abstract
- Effect of formulation on the stability and aerosol performance of a nebulized antibody. Respaud R, Marchand D, Parent C, Pelat T, Thullier P, Tournamille JF, Viaud-Massuard MC, Diot P, Si-Tahar M, Vecellio L, Heuzé-Vourc’h N. MAbs. 2014 Aug 5;6(5) Pubmed abstract
- Nebulization of Antibodies Against Ricine Intoxication By Inhalation. Marchand D., Parent C., Respaud R., Guillemain J., Pelat T., Thullier P., Vecellio L., Heuze-Vourc’h N. RDD Congress 2014, Porto Rico Poster PDF file
- The Performance of a New Vibrating Mesh Prototype Nebulizer For Inhaled Biodrugs. Marchand D., Cabrera M., Pinel M., Nicolini T., Vecellio L. RDD Congress 2014, Porto Rico Poster PDF file
- Influence of Holding Chamber Volume on Performance of Mesh Nebulizers. Marchand D., Cabrera M., Pinel M., Vecellio L. RDD Europe 2015 Congress, Antibes - France Poster PDF file
- Inhaled news drugs and biodrugs: performance of a new vibrating mesh nebulizer. Marchand D., Cabrera M., Pinel M., Vecellio L. ISAM 2015 Poster PDF file
- Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs. Greenblatt EE, Winkler T, Harris RS, Kelly VJ, Kone M, Katz I, Martin A, Caillibotte G, Hess DR, Venegas JG. Regional J Aerosol Med Pulm Drug Deliv. 2016 jun;29(3):260-72 Pubmed abstract
- Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction. Simon M, Vanderpool RR, Nouraie M, Bachman TN, White PM, Sugahara M, Gorcsan J3rd, Parsley EL, Gladwin MT, JCI Insight. 2016 Nov 3;1(18):e89620 Pubmed abstract
Aerodrug, Faculté de Médecine, Bâtiment M, 10 ter boulevard Tonnellé, 37032 TOURS France.